Gerald I Shulman Selected Research

Insulin (Novolin)

1/2021	Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation.
1/2021	Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake.
1/2021	Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease.
12/2020	Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice.
12/2020	Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice.
1/2020	Mechanistic Links between Obesity, Insulin, and Cancer.
11/2019	Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.
2/2019	The effects of increased acetate turnover on glucose-induced insulin secretion in lean and obese humans.
1/2019	Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.
1/2019	Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice.

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Gerald I Shulman Research Topics

Disease

208	Insulin Resistance 01/2022 - 02/2002
68	Type 2 Diabetes Mellitus (MODY) 01/2022 - 03/2002
67	Obesity 01/2022 - 04/2002
42	Non-alcoholic Fatty Liver Disease 01/2022 - 03/2006
29	Hyperglycemia 01/2021 - 02/2002
24	Inflammation (Inflammations) 01/2022 - 05/2002
23	Body Weight (Weight, Body) 01/2022 - 05/2002
14	Fatty Liver 01/2022 - 07/2004
13	Weight Gain 12/2021 - 10/2003
13	Hyperinsulinism (Hyperinsulinemia) 01/2020 - 02/2002
12	Glucose Intolerance 01/2021 - 08/2003
11	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 07/2007
11	Hypertriglyceridemia 01/2022 - 05/2002
9	Weight Loss (Weight Reduction) 10/2020 - 10/2002
9	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/2020 - 01/2002
9	Hypoglycemia (Reactive Hypoglycemia) 01/2019 - 03/2003
6	Hyperlipidemias (Hyperlipidemia) 01/2022 - 05/2007
6	Metabolic Diseases (Metabolic Disease) 10/2020 - 09/2010
6	Hyperphagia (Overeating) 02/2019 - 03/2004
6	Mitochondrial Diseases (Mitochondrial Disease) 12/2017 - 02/2004
6	Lipodystrophy 01/2017 - 05/2002
5	Neoplasms (Cancer) 10/2020 - 04/2011
5	Starvation 11/2019 - 09/2007
4	Fibrosis (Cirrhosis) 01/2021 - 04/2013
4	Necrosis 01/2019 - 02/2012
3	Overnutrition 01/2021 - 12/2011
3	Overweight 11/2020 - 04/2003
3	Ketosis 10/2020 - 02/2017

Drug/Important Bio-Agent (IBA)

124	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 02/2002
111	Insulin (Novolin)FDA Link 01/2021 - 01/2002
100	LipidsIBA 01/2022 - 03/2002
47	DiglyceridesIBA 01/2021 - 02/2002
43	Triglycerides (Triacylglycerol)IBA 01/2022 - 03/2002
34	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 03/2002
17	CeramidesIBA 12/2020 - 02/2002
13	LeptinIBA 01/2020 - 05/2002
13	EnzymesIBA 01/2019 - 03/2004
13	Protein Kinases (Protein Kinase)IBA 01/2018 - 03/2007
12	Acetyl Coenzyme A (Acetyl-CoA)IBA 11/2018 - 03/2006
12	Antisense OligonucleotidesIBA 01/2018 - 03/2006
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2003
11	CarbohydratesIBA 01/2021 - 07/2007
11	GlycogenIBA 01/2020 - 01/2002
10	Acyl Coenzyme A (Acyl CoA)IBA 01/2018 - 02/2002
9	Insulin ReceptorIBA 01/2021 - 09/2002
9	Interleukin-6 (Interleukin 6)IBA 11/2020 - 02/2004
9	Glucagon (Glukagon)FDA Link 01/2020 - 04/2003
8	Phosphotransferases (Kinase)IBA 01/2021 - 07/2006
8	AdiponectinIBA 12/2020 - 02/2004
8	Tyrosine (L-Tyrosine)FDA Link 07/2014 - 09/2002
7	Protein Kinase C-epsilonIBA 01/2022 - 07/2004
7	Hormones (Hormone)IBA 01/2021 - 03/2003
6	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 03/2003
6	CytokinesIBA 11/2020 - 11/2011
6	Acetates (Acetic Acid Esters)FDA Link 02/2019 - 04/2006
6	Glycerol (Glycerine)FDA LinkGeneric 01/2018 - 03/2002
5	Blood Glucose (Blood Sugar)IBA 10/2020 - 06/2003
5	Liver GlycogenIBA 01/2020 - 01/2002
5	AdipokinesIBA 11/2019 - 05/2006
5	Pyruvate CarboxylaseIBA 11/2019 - 07/2013
5	FructoseIBA 10/2019 - 02/2002
5	Insulin Receptor Substrate ProteinsIBA 04/2011 - 12/2002
4	InflammasomesIBA 01/2022 - 02/2012
4	Messenger RNA (mRNA)IBA 12/2021 - 08/2007
4	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 06/2014
4	Serine (L-Serine)FDA Link 10/2020 - 10/2008
4	Fish OilsIBA 02/2020 - 02/2002
4	Protein Isoforms (Isoforms)IBA 12/2019 - 07/2005
4	Protein Kinase CIBA 12/2019 - 11/2011
4	Alanine (L-Alanine)FDA Link 11/2019 - 10/2008
4	fibroblast growth factor 21IBA 01/2019 - 12/2009
4	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 12/2018 - 01/2009
4	Coenzyme A (CoA)IBA 11/2018 - 10/2002
4	Amino Acids FDA Link 01/2018 - 03/2011
4	Adenosine Triphosphate (ATP)IBA 01/2018 - 09/2005
4	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2018 - 04/2007
4	Pyruvic Acid (Pyruvate)IBA 10/2017 - 04/2011
4	Phosphates (Orthophosphate)IBA 10/2016 - 07/2005
4	ResistinIBA 01/2016 - 02/2004
4	Hypoglycemic Agents (Hypoglycemics)IBA 09/2011 - 09/2002
4	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 07/2011 - 07/2005
4	AcyltransferasesIBA 04/2011 - 07/2005
3	Sucrose (Saccharose)IBA 01/2022 - 07/2005
3	Pharmaceutical PreparationsIBA 01/2022 - 03/2007
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 11/2014
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 06/2009
3	LigandsIBA 10/2020 - 02/2002
3	ThiazolidinedionesIBA 10/2020 - 03/2002
3	Acetyl-CoA CarboxylaseIBA 02/2020 - 10/2007
3	Nonesterified Fatty Acids (NEFA)IBA 01/2020 - 12/2004
3	GhrelinIBA 02/2019 - 05/2010
3	GlucocorticoidsIBA 01/2019 - 07/2002
3	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 04/2011
3	CorticosteroneIBA 01/2019 - 07/2002
3	Lipoproteins (Lipoprotein)IBA 01/2018 - 04/2006
3	Growth Hormone (Somatotropin)IBA 01/2018 - 12/2016
3	Uncoupling AgentsIBA 01/2018 - 11/2013

Therapy/Procedure

20	Therapeutics 01/2021 - 05/2002
5	Caloric Restriction 01/2018 - 11/2010
3	Bariatric Surgery 12/2021 - 01/2018